By Michael Fitzpatrick
FORTUNE -- A Japanese startup claims it has cracked the knotty problem of commercializing the production of spider thread, which, gram for gram, is stronger than nylon and even many metals. As one of nature's super-substances -- tougher than Kevlar yet significantly more elastic -- scientists have been trying to recreate it in significant quantities in labs but failed for over a decade.
By using synthetic biology techniques and a new spinning technology, Spiber Inc. says it is now able to produce many hundreds of grams of synthetic spider silk protein where past efforts have produced less than a few grams over a day. One gram of the special protein produces about 9,000 meters (29,527 feet) of silk.
The breakthrough, says the inventor and Spiber's president, Kazuhide Sekiyama, is that unlike other attempts to synthesize spider thread the Japanese researchers did not try to copy the spider's little-understood spinning action. Using duct-like spinnerets, spiders rearrange a simple protein to turn it into silk. "We make fibers using a totally artificial process," he told Fortune.
In the world of biomimicry, or biomimetics, where cutting edge analytical techniques are helping put some of nature's better ideas to work in industry, spider silk is something of a holy grail.
Engineers have been adept up to now at synthesizing a range of extremely useful materials. But they could do better. Kevlar, for example, is a remarkably strong fiber used in aeronautics and bullet-proof vests. Made by heating petroleum products to 1,400 degrees Fahrenheit, then applying substantial pressure, the fiber is teased out to make the final fabric.
To a spider, the process would seem a tad hyperactive. Without using anything like that kind of heat, spiders produce a material that's many times stronger than Kevlar, not to mention biodegradable. Clearly, a synthetic equivalent of spider thread would be of enormous benefit. Biomimetics and synthetic biology helps scientists create spider thread not by copying it exactly but by incorporating some of nature's design aspects. It also shows the potential of such synthetic biology -- breaking down nature into spare parts and then rebuilding them back up as desired.
This can take inventors down some strange avenues. Ten years ago, U.S. researchers came up with the idea of creating "Spider goats" that had their milk genes altered with spider DNA. The resultant animal's milk contained the spider silk protein which was then extracted following milking. After that the task got harder.
So far, what has held scientists back, says Michelle Oyen, professor of Mechanics of Biological Materials at the University of Cambridge, is understanding the natural materials well enough to mimic them. "In the case of spider silk, we can copy the gene sequences responsible for silk and transfer them elsewhere, as with the goat's milk case," she says. "But we then have to mimic the spider's silk spinneret in order to form the proteins into fibers, and that's tricky and has been one of the limitations to date."
Spiber, capitalized at 780 million yen, is now capable of producing up to 1 kg of the silk protein a day and is confident enough to form a joint venture with a Toyota (TM) subsidiary to commercialize production. The yarn proteins at Spiber are made by synthetic microorganisms -- not goat's milk. Spiber is currently building a test plant that will produce 100 kg a month of patented spider thread protein, dubbed Qmonos Fiber, by the end of the year. A pilot plant will then be built for commercialization of the yarn by 2015 that will produce over 10 tons silk annually.
"Applications will include super-light but strong car parts and medical applications," says Sekiyama. "We have an idea for cars that won't hurt pedestrians in crashes." Spider silk's tensile strength but corresponding flexibility could make it ideal for artificial ligaments. One claim, however, that Prof. Oyen wishes to disabuse us of, is that spider silk is stronger than steel. "At best, spider silk might compare to steel when it comes to tensile strength. Tensile strength is only one critical property," she says. "The stiffness of silk, which is its ability to deform elastically when force is applied, is many times less than that of steel."
Nevertheless, Spiber is not alone in the race to market such a potentially valuable substance. German firm Amsilk recently announced it, too, will start a pilot project to scale up lab production of spider silk. Meanwhile, the American company that originally created the spider goats, after securing millions of dollars in backing, is no longer in the spider web business. The goats, now a Utah university farm, still produce spider proteins. But for the time being, the protein-synthesizing micocrobes seem to have the lead.
Manufacturers have spent years building low-cost global supply chains. Natural disasters are showing them just how delicate those networks really are.
By Bill Powell, editor-at-large
FORTUNE -- The image to the right is almost surreal: It shows part of a Honda auto factory in central Thailand, one of the largest in Southeast Asia, swamped under 15 feet of water, brand-new cars floating in the currents. The devastating November flooding in Thailand, which MOREDec 12, 2011 11:21 AM ET
The Japanese automaker was a perennial also-ran, behind Honda and Toyota. Until now. Nissan is making deft moves just as its rivals stall.
By Doron Levin, contributor
FORTUNE -- Japan's auto industry has been battered by disasters natural and unnatural unlike this year. A tragic earthquake and a steroidal yen have wreaked havoc on the bottom lines of major firms Honda and Toyota. The exception? Nissan. The perennial third place finisher has MOREAug 23, 2011 8:56 AM ET
Every day, the Fortune staff spends hours poring over tech stories, posts, and reviews from all over the Web to keep tabs on the companies that matter. We've assembled the day's most newsworthy bits below.Those of you jonesing to get the latest tech news as it happens can sign up for the "Today in Tech" newsletter. So get to it!
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Every day, the Fortune staff spends hours poring over tech stories, posts, and reviews from all over the Web to keep tabs on the companies that matter. We've assembled the day's most newsworthy bits below.
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A round-up of the companies, deals, and trends that made headlines.
Every day, the Fortune staff spends hours poring over tech stories, posts, and reviews from all over the Web to keep tabs on the companies that matter. We've assembled the day's most newsworthy bits below.Ex-IBM exec Robert Moffat was sentenced to six months in jail, (See: After the sentencing: What's ahead for Robert Moffat) two years of supervision, and ordered to MORE JP Mangalindan, Writer - Oct 14, 2010 7:57 AM ET
Big carmakers say they're developing driverless cars, but only the search engine company has taken to California's highways with one. If driverless cars can pick up people at their home or office, the need to buy one at all may soon be gone.
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China, oil prices and the environment are pushing electric cars to the tipping point
By Oliver Hazimeh, Director, PRTM
The recall of Toyota's Prius has some observers questioning the prospects for the entire electric vehicle marketplace. They shouldn't: The fundamental forces for electrifying our cars and infrastructure are still in place.
While Toyota (TM) and Honda (HMC) have found success with traditional hybrid electric vehicles (HEVs) that are powered by an internal combustion MOREApr 7, 2010 12:15 PM ET
In the age of global enterprise software, US carmakers are re-learning the secrets of efficiency
By Fred Thomas, Industry Director, Apriso
After the government provided a $17.4 billion lifeline to two of the largest US automakers last year, most Americans still thought that the big Detroit three – GM, Chrysler and Ford – were down for the count.
Over the last few decades, we've seen domestic car sales from American companies slide from MOREApr 5, 2010 1:53 PM ET
Steve Jobs' company wins the annual industry poll by the highest margin ever
It's Apple by a landslide.
For the third time running, Apple Inc. has been named the most admired company in the world in Fortune's annual ranking.
Moreover, in a poll of 4,200 executives, directors and industry analysts it was voted No. 1 by the highest margin ever.
"What makes Apple so admired?" asks Christopher Tkaczyk in Apple's write-up. "Product, product, product. MOREPhilip Elmer-DeWitt - Mar 4, 2010 10:31 AM ET
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